Ground-breaking Microbubble Technology
Targeted Drug Delivery
SonoTarg has developed a suite of microbubble-based therapeutics for treating solid tumours with targeted, low dose chemotherapy and sonodynamic therapy (SDT).
Each microbubble delivers rose bengal sonosensitiser which elicits SDT when activated by ultrasound, causing cancer cell death.
One or more chemotherapy drugs can also be incorporated into the microbubble structure to target different cancer types.
Mechanism of Action:
1
Ultrasound disrupts the microbubble at the target tumour, releasing the therapeutic payload.2
Ultrasound activates the sonosensitiser, eliciting SDT.3
Ultrasound enhances dispersal and uptake of the therapeutics by the surrounding tumour tissues.4
The chemotherapy and activated sonosensitiser cause target cell death.5
The immune system is engaged further enhancing local efficacy and enabling the treatment of metastatic disease.